I've had the S20 evo's (190/50) and the S21's (200/55). Both lasted close over 10,000 with both commuting and very spirited rides. My summer commute includes a combination of highway, back roads and twisty mountain track. Winter up here is cold and wet with mostly highway.
I can say the S21's are far and above a better tire than the S20's but the slipping mention frequently on the 20's was not as extreme as some indicate. For me at least. I imagine pressures and riding style would vary this a lot.
The S20's slipping was more of a "step out" and grab imho. Almost like the sidewall would collapse then rebound. Now I know this wasn't the case but it was unnerving even if predictable. During cold and wet rides this step out was less pronounced but of course this was due to less speed and lean. They did heat up well however and kept their heat.
The S21's, for me at least, was the tits. They were very predictable and grabbed far better than they had a right to. The front felt like the bike was chained down and I could ride it's edge all day without fade no matter what the temperature. The higher profile allowed quicker turn in but they produced zero fall into corners. Just even roll out to the edges. Cold and rain were not an issue as these too would heat up fast and keep the heat soak going when stopped for a while. One negative I will mention and everyone can evaluate if it is in fact a negative, would be a definitive transition between compounds in the rear when leaning hard. Nothing abrupt but there none the less. The front displayed none of these symptoms. Maybe due to the three compound as opposed five compound of the rear.
In the end I wouldn't hesitate to recommend the S21's and given their similar price to the S20's I'd say skip to the 21's without question and enjoy. Hope this helps someone.